Hypotensive effect of clonidine during sodium depletion in the rat.
نویسندگان
چکیده
منابع مشابه
Hypotensive effect of clonidine during sodium depletion in the rat.
Clonidine was nonhypotensive in conscious unrestrained rats maintained on a normal sodium intake. In contradistinction, clonidine caused a dose-related hypotension in conscious unrestrained rats subjected to sodium depletion via furosemide. The plasma renin activity of normal and sodium-depleted rats was reduced after the administration of clonidine (100 mug/kg, iv) by 22.8% and 34.4%, respecti...
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Apparent resistance to hypotensive effect of clonidine.
Clonidine failed to reduce the blood pressures of two patients with essential hypertension. On was given 5-4 mg/day and the other 6 mg/day, and their respective peak plasma clonidine concentrations were 26-2 ng/ml and 14-4 ng/ml. Several months after the end of clonidine treatment a single oral dose of 0-3 mg of clonidine produced maximum falls in blood pressure of 30/22 mm Hg and 88/41 mm Hg w...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1975
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.37.6.795